Incumbent Democratic senator Bill Nelson recently confirmed to CNN that he would be running for a fourth term in 2018. Nelson has the benefit of seniority in the Senate, as well as the fact that his previous two reelections (2006 and 2012) were in very favorable cycles, as was the case for Senate Democrats in general who were elected or re-elected in those years.
One potential Republican who is interested in running for the seat is Governor Rick Scott, who is term-limited from running again for governor in that same year. Scott would enter the Republican field with the advantages of name-recognition, fundraising, networking, as well as the fact that he has already won two consecutive statewide races. On top of all of that, he was an early supporter of Donald Trump, who would presumably campaign heavily on his behalf in the midterms if he chooses to run for Senate.
If this is the matchup for November 2018, Florida will be a long and very expensive race.